饮食维生素E摄入量与发生心血管疾病,心血管疾病和全因死亡率之间的关联:使用NHANES 2003-2018数据的前性队列研究
Qingping Zeng1,2, Mengqian Liao1,3, Yu Li4
1School of Clinical Medicine, Tsinghua University, Beijing, 102218, China.
概括
饮食中较高的维生素E摄入量与较低的心血管疾病风险和全因死亡率有关. 这些发现表明,富含维生素E的饮食可能促进心血管健康并降低死亡率.
科学领域:
- 营养科学 营养科学
- 心血管健康 心血管健康
- 流行病学 流行病学
背景情况:
- 饮食维生素E与心血管疾病 (CVD) 风险以及死亡率之间的联系尚未完全理解.
- 这项研究通过检查大量,代表性的美国人口样本来解决不确的证据.
研究的目的:
- 调查饮食维生素E摄入量与心血管疾病风险之间的关联.
- 检查饮食维生素E摄入量与心血管和全因死亡率之间的关系.
主要方法:
- 分析了2003-2018年国家健康和营养检查调查 (NHANES) 的39293名参与者的数据.
- 通过24小时召回评估饮食维生素E摄入量;结果包括事件CVD,CVD死亡率和全因死亡率.
- 权重后勤和考克斯回归模型,调整了混因子,并使用受限立方线 (RCS) 分析来评估非线性关系.
主要成果:
- 较高的维生素E摄入量 (≥9.86毫克/天) 与最低四分位数 (<4.08毫克/天) (OR=0.57,P趋势<0.01) 相比,与心血管疾病发生率降低43%有关.
- 较高的维生素E摄入量与全因死亡率的降低有关 (HR=0.85,P趋势=0.04),但与心血管疾病死亡率的降低无关 (HR=0.96,P趋势<0.001).
- 对大多数结果观察到非线性关联,包括心血管疾病,冠状动脉疾病,心脏病发作,中风和全因死亡率 (所有P-非线性<0.05).
结论:
- 饮食中较高的维生素E摄入量与美国人口中心血管疾病和全因死亡率显著降低的风险有关.
- 这些发现支持富含维生素E的饮食对改善心血管健康和降低死亡率的潜在益处.
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