怀孕和心血管疾病:PREG-CVD-HH注册表
Dora Csengeri1,2, Elisabeth Unger1,2, Jessica Weimann1
1Department of Cardiology, University Heart & Vascular Center, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Cardiovascular diagnosis and therapy
|January 10, 2025
概括
怀孕暂时会恶化心脏功能,并增加心血管疾病 (CVD) 的女性的生物标志物. 这些变化在分娩后逆转,突出了需要专门的"怀孕心脏团队"来提供最佳的孕产妇护理.
科学领域:
- 心脏病学 心脏病学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 心血管生理学心血管生理学
背景情况:
- 心血管疾病 (CVD) 是西方国家孕产妇死亡的主要原因.
- 怀孕引起的生理变化可能会加剧孕妇的先前存在或导致新的心血管并发症.
- 患有心血管疾病的妇女在怀孕期间面临更高的风险,需要专门的监测和护理.
研究的目的:
- 描述怀孕引起的心脏功能变化和心血管疾病妇女的生物标志物水平.
- 为了评估怀孕妇女的心血管结果,预先存在或与怀孕相关的心血管疾病.
- 为了解决患有心脏病的孕妇的管理提供见解.
主要方法:
- 63名患有心血管疾病的孕妇和10名对照的前性,单中心观察性研究 (PREG-CVD-HH).
- 在整个怀孕和产后期间,全面的心声回声和对心脏生物标志物 (NT-proBNP,MRproADM,hs-cTnI) 的连续测量.
- 确定的母亲心脏事件包括死亡,心律失常,心力衰竭和住院治疗.
主要成果:
- 观察到的左和右心室全球纵向应变的过渡性恶化在妊娠的第三季度和周周.
- 在怀孕期间增加NT-proBNP和hs-cTnI的上升趋势,产后正常化.
- 14.1%的人患有新发性心力衰竭;21.2%的人因心血管事件住院. 没有发生产妇死亡.
结论:
- 怀孕与患有心血管疾病的妇女的过渡性心脏生物标志物升高和功能变化有关.
- 这些变化通常在分娩后逆转,可能是由于心脏负荷降低和液体转移.
- 专门的 专业的 专业的
- 怀孕心脏团队 怀孕心脏团队
- 建议进行怀孕前咨询和持续管理,以优化患有心血管疾病的孕妇的治疗结果.
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