相关实验视频

Updated: May 10, 2026

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: November 1, 2010

诺福维尔时代的艾滋病毒和CKD:坦桑尼亚的一项前性并行组队列研究

Nicholas L S Roberts^1,2, Salama Fadhil^2,3, Megan Willkens¹

¹Center for Global Health, Weill Cornell Medicine, New York, NY.

Kidney medicine

|January 10, 2025

概括

在撒哈拉以南非洲,感染艾滋病毒的人 (PLWH) 接受基于tenofovir disoproxil fumarate的抗逆转录病毒疗法 (ART) 经历了高慢性病 (CKD) 发病率和更快的eGFR下降. 用ART稳定了白膜尿,这表明需要更少的毒性ART选择.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

撒哈拉以南非洲的慢性病 (CKD) 研究,特别是在艾滋病毒感染者 (PLWH) 中,是有限的.
了解PLWH中CKD发生率和进展对于有效的管理和治疗策略至关重要.

研究的目的:

评估PLWH中慢性瘤的发病率,与坦桑尼亚的未感染艾滋病毒的个人相比.
评估艾滋病毒状况,抗逆转录病毒疗法 (ART) 与CKD发展和进展之间的关联.

主要方法:

一项前性队列研究,涉及495名新诊断的PLWH开始ART和505名未感染HIV的对照.
从2016年到2021年,参与者进行了跟踪,每年评估估计的膜过率 (eGFR) 和albuminuria.
统计分析包括多变量回归来确定HIV,ART和CKD结局之间的关联.

主要成果:

慢性病发病率在PLWH中明显高 (57.9每1000人年),与未感染HIV的个人相比 (26.2每1000人年).
与对照组 (-2.61 mL/min/1.73 m2每年) 相比,PLWH的eGFR下降速度更快 (-6.65 mL/min/1.73 m2每年).
虽然白蛋白尿的发病率与艾滋病毒状况没有差异,但基线白蛋白尿的PLWH面临更高的死亡风险.

结论:

在撒哈拉以南的非洲,基于丁诺福维尔二二醇烟酸的ART与CKD的高发病率和PLWH的加速eGFR下降有关.
尽管存在毒性问题,ART使用似乎稳定了白蛋白尿,这表明有潜在的益处.
在撒哈拉以南非洲地区,迫切需要扩大对较少毒性ART疗法 (如tenofovir alafenamide) 的使用范围,以减轻CKD负担.

关键词:

抗逆转录病毒药物治疗艾滋病病毒艾滋病病毒艾滋病病毒慢性脏疾病慢性脏疾病流行病学流行病学全球卫生健康全球卫生健康这种药物是tenofovir.

更多相关视频

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 10, 2014

相关概念视频

Retrovirus Life Cycles

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...

Sexually Transmitted Infections

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...

Pulmonary Tuberculosis I

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...