在严重的COVID-19引起的肺纤维化中,肺动脉Vasa Vasorum损伤
Weijian Huang1, Tara D Richards1, David J Kaczorowski1,2
1Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
COVID-19增加了肺动脉的血管密度和免疫血栓形成,影响大血管功能,并可能导致严重疾病患者的器官衰竭.
科学领域:
- 心血管病理学心血管病理学
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19与动脉和静脉血栓的增加有关,特别是在肺部.
- 血管,供应大动脉的小血管,与这些COVID-19相关的血管病理有关.
研究的目的:
- 为了调查COVID-19感染导致的肺动脉微血管损伤的程度.
- 为了比较非COVID-19肺纤维化患者和健康器官捐赠者的COVID-19患者的vasa vasorum特性.
主要方法:
- 主,右或左肺动脉样本的组织学和免疫组织学分析.
- 来自肺移植接受者 (COVID-19和非COVID-19相关纤维化) 和器官捐赠者的样本的比较.
主要成果:
- 与肺移植捐赠者相比,在COVID-19患者的肺动脉中观察到肺血管密度增加.
- 在COVID-19患者的Vasa vasorum中显示出免疫血栓形成,CD15+,CD44+和CD68+免疫细胞的显著透.
- 在COVID-19患者中,较高的vasa vasorum密度与肺动脉高血压相关.
结论:
- COVID-19 感染显著影响肺动脉的血管.
- 血管损伤可能导致COVID-19患者的大血管功能障碍和器官衰竭.
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