在三级医院接收的CBNAAT样本中肺外结核的分布 - 一项基于记录的研究
Soumyya Mondal1, Anwesha Mandal1, Sipra Saha1
1Department of Microbiology, College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal, India.
Journal of family medicine and primary care
|January 10, 2025
概括
肺外结核 (EPTB) 是一个严重的健康问题,特别是在年轻女性. 早期诊断和治疗对于管理EPTB至关重要,GeneXpert MTB/RIF测定在识别疾病方面被证明是有效的.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 肺结核 (PTB) 占全球结核病例的85%.
- 肺外结核 (EPTB) 可以独立表现或与PTB一起表现,影响各种器官.
- 基于子的核酸放大测试 (CBNAAT) 已被建立用于诊断PTB.
研究的目的:
- 通过CBNAAT分析的不同样本类型分析EPTB的分布.
- 确定与EPTB相关的人口结构模式和风险因素.
主要方法:
- 一项回顾性横截面研究分析了2020年1月至2022年12月期间疑似EPTB患者的数据.
- 基因Xpert MTB/RIF测定用于处理1118个肺外样本.
- 使用Excel和Open-epi软件进行了统计分析.
主要成果:
- 在1118个样本中,22% (249) 的人检测出Mycobacterium tuberculosis (MTB) 的阳性.
- 大多数阳性样本 (55%) 来自女性患者,21-30岁年龄组受影响最大.
- 淋巴结吸附物 (47%) 和肺部液体 (13%) 是最常见的阳性样本类型.
结论:
- 年龄较小 (三十岁) 和女性性别可能是EPTB的风险因素.
- 及时诊断和治疗对于降低EPTB发病率和死亡率至关重要.
- 建议针对女性的EPTB进行有针对性的调查,并推广BCG疫苗接种.
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