患有输血依赖性沙拉西米亚儿童的周围神经病变的患病率:一项基于医院的横截面研究
Aniruddha Rathore1, Mukesh Dhankar1, Sharmila B Mukherjee1
1Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India.
Journal of family medicine and primary care
|January 10, 2025
概括
周围神经病变在患有输血依赖性沙拉西米亚的儿童中很常见,即使没有症状. 异常神经传导研究 (NCS) 与贫血和化持续时间相关,强调需要进一步研究.
科学领域:
- 儿科神经学 儿科神经学
- 血液学 血液学 血液学
- 临床电生理学 临床电生理学
背景情况:
- 输血依赖性thalassemia是一种慢性疾病,需要定期输血.
- 周围神经病变是这些患者的潜在并发症.
- 神经传导研究 (NCS) 对于诊断外围神经病变至关重要.
研究的目的:
- 确定患有输血依赖性血症的儿童 (5-18岁) 中外围神经病变的患病率.
- 调查外围神经病变与贫血,费里丁,化和维生素水平等因素之间的相关性.
主要方法:
- 一项涉及100名患有输血依赖性沙拉西米亚的儿童的横截面研究.
- 进行了神经学检查和NCS.
- 根据年龄的截止值 (2.5 SD 从正常) 定义了异常.
主要成果:
- 77%的儿童表现出NCS异常,尽管没有神经病变的临床迹象.
- 纯运动神经变化 (33%) 和混合神经变化 (26%) 最常见.
- NCS异常与慢性贫血和铁化持续时间有显著的相关性.
结论:
- 亚临床外围神经病变在患有输血依赖性沙拉西米亚的儿童中普遍存在,通常与血红蛋白水平低于9.5g/dl相关.
- 需要进一步的研究来确定最佳的血红蛋白标和化疗的作用.
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