对177Lu-DOTATATE的辐射安全评估 动脉内受体治疗 (PRRT)
Manoj Kumar Hariram Chauhan1,2, Ashish Kumar Jha3,4, Sneha Mithun3,4
1Department of Nuclear Medicine and Molecular Imaging, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Mumbai, Maharashtra, India.
概括
这项研究测量了干预放射科医生在177Lu-DOTATATE静脉内受体放射性核酸治疗 (PRRT) 期间的辐射暴露. 结果表明,医务人员的辐射剂量在安全范围内,确保了手术安全.
科学领域:
- 核医学就是核医学.
- 干预性放射学 干预性放射学
- 辐射瘤学 辐射瘤学
背景情况:
- 177Lu-DOTATATE受体放射性核酸疗法 (PRRT) 是神经内分泌瘤的关键治疗方法.
- 动脉内PRRT越来越多地用于肝转移.
- 评估医疗专业人员的辐射安全至关重要.
研究的目的:
- 为量化干预放射科医生在动脉内177Lu-DOTATATE PRRT.期间所收到的辐射剂量.
- 为了评估医疗保健提供者执行此程序的辐射安全.
主要方法:
- 在31次手术期间,放射科医生在手,眼睛和胸部水平上连续测量了辐射暴露.
- 患者表面和1米距离的辐射水平被记录在施用后.
- 计算了放射科医生和患者的平均辐射剂量.
主要成果:
- 平均给药活性为194 (±17) mCi.
- 患者肝脏水平表面的平均辐射暴露量为100 (±25.11) μSv/hr.
- 放射科医生的手和眼睛每次手术的平均辐射剂量分别为6.425 ± 2.75 μSv和5.43 ± 1.76 μSv.
结论:
- 给药后患者的辐射暴露低于出院限值.
- 干预放射科医生的辐射剂量在允许的范围内.
- 动脉内177Lu-DOTATATE PRRT是辐射专业人员的一种安全程序.
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