氧化低密度脂蛋白是否与慢性,非肝硬化HCV患者的肝脏外表现有关?
Dina Johar1, Ahmed Hamed Bedair El-Assal2, Mahmoud Mohamed Abou-El-Makarem3
1Department of Biochemistry and Nutrition, Faculty of Women for Arts, Sciences and Education, Ain Shams University, Heliopolis, Cairo, Egypt.
Metabolism open
|January 10, 2025
概括
肝炎C病毒 (HCV) 感染导致氧化LDL (ox-LDL) 在患者中增加,特别是那些有肝外表现的人. 高氧-LDL水平与慢性HCV的抗氧化酶表达放松调节有关.
科学领域:
- 肝病学和病毒免疫学
- 氧化应激和心血管疾病
背景情况:
- 病毒性肝炎,特别是C型肝炎病毒 (HCV) 感染,是全球重要的健康问题,导致发病率和死亡率.
- 肝炎病毒感染通过各种途径引发氧化和化应激,包括INOS,线粒体功能障碍和NOX酶,导致氧化低密度脂蛋白 (ox-LDL) 的形成.
- 型肝炎感染还会通过减少减少谷氨酸 (GSH) 的合成和再生来损害身体的抗氧化防御.
研究的目的:
- 为量化血清氧化低密度脂蛋白 (ox-LDL) 水平在慢性,非肝硬化型肝炎C病毒 (HCV) 感染的患者.
- 为了研究血清氧-LDL水平与HCV患者的肝外表现之间的关联.
- 评估ox-LDL与细胞外抗氧化酶,超氧化脱酶 (EC CuZn-SOD) 之间的关系.
主要方法:
- 采用了横截面研究设计.
- 从三个组收集血清样本:具有肝外表现的慢性HCV患者,没有肝外表现的慢性HCV患者和健康对照.
- 在所有参与者中测量了肝功能测试,ox-LDL水平和EC CuZn-SOD活性.
主要成果:
- 与没有 (63.05 ± 6.6 μg/L) 的患者相比,具有肝外表现的患者表现出显著更高的血清氧-LDL水平 (76.63 ± 6.86 μg/L) (p < 0.001).
- 这两组HCV患者的ox-LDL水平明显高于健康对照组 (44.1 ± 4.1 μg/L) (p < 0.001).
- 在EC CuZn-SOD和ox-LDL之间的负相关性仅在具有肝外表现的HCV患者中观察到.
结论:
- 在慢性HCV感染中,肝外表现与血清氧-LDL水平升高有关.
- 慢性HCV患者的高血清ox-LDL水平可能与血清EC CuZn-SOD表达失调有关或由此引起.
- 肝外表现似乎不是HCV感染中人类学变化的风险因素.
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