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Updated: Jun 3, 2025

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
09:16

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

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抑制H3K27脱甲基酶降低CREB-CREBBP,克服复发性急性淋巴细胞白血病中的抵抗

Juan Lazaro-Navarro1,2, Clara Alcon3,4, Mathurin Dorel5

  • 1Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Cancer medicine
|January 10, 2025
PubMed
概括

这项研究表明,用GSK-J4抑制H3K27脱甲基酶可以克服急性淋巴细胞白血病 (ALL) 的耐药性. 高CREBBP表达预测了对GSK-J4的敏感性,建议将其作为治疗的生物标志物.

关键词:
灭症 (apoptosis) 是一种死亡的过程.药物发现和输送.表观遗传学是指表观遗传学.这种白血病是白血病.

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