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Updated: Jun 3, 2025

Pooled shRNA Library Screening to Identify Factors that Modulate a Drug Resistance Phenotype
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在B细胞急性淋巴细胞白血病中,DNTT介导的DNA损伤反应驱动了inotuzumab臭加米辛的耐药性

Carolin S Escherich1,2, Takaya Moriyama1, Zhenhua Li1

  • 1Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.

Blood
|January 10, 2025
PubMed
概括

在B细胞急性淋巴细胞白血病 (B-ALL) 患者中,DNA核样脱氧转移酶 (DNTT) 损失驱动了对伊诺图祖马布臭胺 (InO) 治疗的耐药性. DNTT下调会损害DNA损伤反应,为个性化B-ALL治疗提供潜在的生物标志物.

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