在患有慢性精神分裂症的患者中,动脉/萨尔科佩尼亚,超金字塔症状,负面症状,身体组成和营养状况之间的关联
Reiko Kamoi1, Yoshihiro Mifune1, Krishan Soriano2,3
1Mifune Hospital, Kagawa 763-0073, Japan.
Healthcare (Basel, Switzerland)
|January 10, 2025
概括
慢性精神分裂症患者往往会经历动力症和肉症,这与负面症状和日常活动受损有关. 关键指标,如BUN/肌素比和巴特尔指数,可以帮助检测肌肉损失的风险.
科学领域:
- 老年学是一门学科.
- 精神病学是一个精神病学.
- 营养科学 营养科学
背景情况:
- 慢性精神分裂症与各种身体健康问题有关.
- 在精神分裂症患者中,外皮拉米德症状 (EPS) 是常见的.
- 肌肉衰弱和损失的特征为动力衰弱和肉类衰弱,是这个人群中新出现的担忧.
研究的目的:
- 调查慢性精神分裂症,EPS,身体组成,营养状况和dynapenia/sarcopenia之间的关联.
- 鉴定精神分裂症患者中恐纳和萨尔科佩尼亚的潜在风险因素和指标.
主要方法:
- 分析了68名慢性精神分裂症患者的数据.
- 使用了斯皮尔曼的rho,克鲁斯卡尔-瓦利斯,曼-惠特尼U测试和克拉梅尔的V统计.
- 评估握力,骨肌肉指数,步行速度,营养指标和功能状态 (巴特尔指数).
主要成果:
- 确定了动脉 (39.7%) 和肉 (27.9%) 的患病率.
- 与肌肉强度和功能减少相关的负面症状.
- 年龄与增加EPS严重程度和降低抗精神病剂量相关.
- 血液尿素 (BUN) /肌素比率与肉症风险指标负相关.
- 动脉缩症/肉症组显示营养状况较差,肌肉质量减少.
- 通过巴特尔指数 (BI) 测量的日常生活活动 (ADL) 与恐慌症 / 麻醉症有关.
结论:
- BUN/肌素比率,BI,EPSs,BMI,握力,总蛋白质和白蛋白是检测/肉风险的有价值指标.
- 常规精神病治疗可以将这些指标纳入早期检测和干预的指标.
- 解决肌肉衰弱对于改善精神分裂症患者的功能结果至关重要.
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