在患有不同类风湿病症的患者中探索患者激活和遵守
Haya M Almalag1, Nora Alosaimi1, Reem Alqahtani1
1Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Healthcare (Basel, Switzerland)
|January 10, 2025
概括
患者激活水平在各种类风湿病症中有所不同,轴性脊柱关节炎患者的遵守程度更高. 系统性红斑狼的疾病活性与患者激活率较低相关.
科学领域:
- 类风湿病学 类风湿病学
- 患者为中心的护理
- 健康研究成果研究结果
背景情况:
- 患者激活,衡量个人管理健康的知识,技能和信心,在慢性疾病中至关重要.
- 了解系统性红斑狼 (SLE),牛皮性关节炎 (PsA) 和轴性脊柱关节炎 (axSPA) 的患者激活,可以告知有针对性的干预措施.
研究的目的:
- 为了评估和比较患者激活使用患者激活测量13 (PAM-13) 跨患者的SLE,PSA和axSPA.
- 调查患者激活,药物遵守和这些类风湿病的疾病活动之间的关系.
主要方法:
- 一项涉及418名患有SLE,PsA或axSPA的患者的横截面研究,通过诊所和社交媒体招募.
- 通过电子方式收集的数据包括人口统计数据,PAM-13分数,风湿病学阿拉伯合规问卷 (ACQR) 和疾病活动分数.
- 统计分析包括奇平方测试,线性回归和二进制物流回归.
主要成果:
- 在这三种类型的风湿病中,PAM-13评分没有显著差异.
- 与SLE和PsA患者相比,axSPA患者的药物服药能力显著提高 (p=0.012).
- 肺炎患者更有可能处于较低的激活水平 (OR=2.890),而axSPA患者更有可能处于更高的激活水平 (OR=2.460). 系统性狼发疹病活动指数 (SLEDAI) 的得分与PAM-13得分 (r=-0.221,p<0.001) 呈反向关系.
结论:
- 患者激活和药物服药水平在不同类型的风湿病症之间有所不同.
- 轴性脊椎关节炎患者表现出更好的服从性,而SLE中的疾病活性对患者激活产生了负面影响.
- 建议对更大的队列进行进一步的研究,以验证研究结果并探索增强患者激活和遵守策略.
相关概念视频
T Cell Types and Functions
946
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
946
Drug Therapy
37
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
37
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
141
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
141
The JAK-STAT Signaling Pathway
8.7K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.7K
Inflammatory Bowel Disease IV: Pharmacological Management
110
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
110
Autoimmune Disorders
385
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
385


