洞穴林介导的内细胞分裂:利用细菌病原体和宿主-病原体相互作用.
Dibyasri Barman1, Rishi Drolia1
1Molecular and Cellular Microbiology Laboratory, Department of Biological Sciences, Old Dominion University, Norfolk, VA 23529, USA.
Cells
|January 10, 2025
概括
细菌病原体利用宿主细胞洞穴机械进入,细胞内生存和免疫逃避. 了解这种操纵揭示了潜在的治疗目标,防止微生物入侵.
科学领域:
- 细胞生物学 细胞生物学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 哺乳动物细胞利用不同的内细胞通路进入病原体.
- 洞穴介导的内细胞结合症涉及脂质丰富的洞穴和洞穴蛋白质.
- 细菌病原体经常劫持宿主细胞内细胞机制进行入侵.
研究的目的:
- 要总结细菌病原体如何操纵宿主洞穴系统.
- 突出卡韦林在细菌进入,细胞内生存和免疫逃避中的作用.
- 为了确定洞穴林通路内的潜在治疗点.
主要方法:
- 关于细菌病原和宿主细胞相互作用的文献综述.
- 细菌操纵中华素中介性内细胞分裂的分析.
- 洞穴在细菌入侵和免疫调节中的作用的概述.
主要成果:
- 细菌病原体如*Listeria monocytogenes*,A组链球菌,Escherichia coli*K1,*Klebsiella pneumoniae*,*Pseudomonas aeruginosa*和*Salmonella enterica*serovar Typhimurium都使用了.
- 卡维奥林促进了细菌的内部化,转移,细胞传播和细胞内生存.
- 卡韦林的病原体操纵有助于逃避免疫反应并触发炎症.
结论:
- 细菌病原体广泛利用宿主的洞穴系统成功感染.
- 准卡韦林通路为开发新型抗菌疗法提供了一个有前途的战略.
- 进一步研究卡韦林-宿主-病原体相互作用对于对抗传染病至关重要.
关键词:
李斯特里亚单细胞原生菌Listeria monocytogenes洞穴 (caveolae) 是一个洞穴.卡维奥林-1 卡维奥林卡维奥林二号 - 卡维奥林二号卡维奥林-3是什么意思细胞内症是指内细胞内症.主体病原体相互作用免疫逃避 免疫逃避微生物入侵 微生物入侵更多相关视频
10:29Applying Fluorescence Resonance Energy Transfer FRET to Examine Effector Translocation Efficiency by Coxiella burnetii during siRNA Silencing
Published on: July 6, 2016
10.6K
09:25Quantification of Cytosolic vs. Vacuolar Salmonella in Primary Macrophages by Differential Permeabilization
Published on: July 28, 2015
10.9K
相关概念视频
Receptor-mediated Endocytosis
104.0K
Overview
104.0K
Intracellular Movement of Viruses and Bacteria
2.8K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
2.8K
Clathrin Coated Vesicles
6.8K
Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
6.8K
Endocytosis
9.0K
Eukaryotic cells acquire nutrients for growth and proliferation. Nutrients and other molecules that require degradation are internalized from the extracellular space by a process called endocytosis. The term ‘endocytosis' was first coined by Christian de Duve in 1963.
Endocytosis always begins with the plasma membrane enclosing an incoming molecule to form a transport vesicle which, in some cases, can be coated with a protein called ‘clathrin.' Endocytosed material is either...
Endocytosis always begins with the plasma membrane enclosing an incoming molecule to form a transport vesicle which, in some cases, can be coated with a protein called ‘clathrin.' Endocytosed material is either...
9.0K
Recycling Endosomes and Transcytosis
2.6K
The recycling endosome, also known as the endosomal recycling compartment (ERC), is a part of the slow-recycling process of the endocytic pathway. Molecules internalized through receptor-mediated endocytosis are either degraded in the lysosomes or are recycled to the plasma membrane through the fast- or slow-recycling route.
The recycling endosome is not a single organelle but an extensively tubulated network of recycling pathways. It functions in storing molecules or transporting them across...
The recycling endosome is not a single organelle but an extensively tubulated network of recycling pathways. It functions in storing molecules or transporting them across...
2.6K
Phagocytosis
6.1K
Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis ("cellular eating") is one of three major types of endocytosis. Cells use phagocytosis to take in large objects, such as other cells (or their debris), bacteria, and even viruses.
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells,...
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells,...
6.1K
