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作为对母亲肥胖的反应,骨髓髓骨髓细胞的代谢和转录重塑

Yem J Alharithi¹, Elysse A Phillips¹, Tim D Wilson¹

¹Knight Cardiovascular Institute, School of Medicine, Oregon Health & Science University, Portland, Oregon, United States.

American journal of physiology. Endocrinology and metabolism

|January 10, 2025

概括

孕产妇的肥胖会改变后代的骨髓脂质代谢,导致免疫代谢功能障碍. 这些早期的变化可能会使后代容易患成人肥胖和心脏代谢疾病.

科学领域:

免疫代谢过程中的免疫代谢.
发展生物学发展生物学
孕产妇健康孕产妇健康

背景情况:

孕产妇的肥胖会增加后代患肥胖和心脏代谢疾病的风险.
以前的研究发现,肥胖母亲的后代的骨髓中存在免疫干扰.
这些后代的骨髓中的脂质代谢在很大程度上仍未被探索.

研究的目的:

为了研究饮食诱导肥胖的母亲的后代的骨髓内脂质代谢的变化.
为了描述这些后代骨髓髓髓质细胞的免疫代谢特征.

主要方法:

使用一种小鼠模型,研究母亲高脂肪饮食 (HFD) 诱导的肥胖症.
在骨髓细胞和从3周大的后代中分离的CD11b+骨髓细胞上进行了脂质组,代谢组和转录组分析.
将高度养母亲 (Off-HFD) 的后代与常规养母亲 (Off-RD) 的后代进行比较.

主要成果:

养HFD母亲的后代表现出增加的脂肪和明显的骨髓脂质配置,包括改变的二甲基甘油 (DAG),三甲基甘油 (TAG),脂和脂.
胆固醇缩,表明胆固醇输送减少,伴随着线粒体功能障碍.
骨髓状细胞表现出类似的脂质组变化 (DAG增加,TAG减少) 和免疫路径中的基因表达变化.

结论:

早期暴露于孕产妇肥胖导致骨髓和骨髓细胞中显著的脂质,代谢和基因表达异常.
这些在早期发育中的免疫代谢干扰可能会导致成人开始肥胖和心脏代谢疾病的风险增加.
不良的子宫内环境会影响骨髓代谢,可能会影响后来的免疫反应.

关键词:

骨髓骨髓骨髓骨髓骨髓健康和疾病的发展起源 (DOHAD)发展规划是指发展规划.孕产妇的肥胖症母亲的肥胖症骨髓状细胞是骨髓状细胞.

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