终身炼可以抵消与衰老相关的低级炎症吗? 一个系统的审查和元分析
Iñigo M Pérez-Castillo1, Ricardo Rueda2, Hakim Bouzamondo3
1Research and Development, Abbott Nutrition, 68 Camino de Purchil, 18004, Granada, Spain. inigomaria.perez@abbott.com.
Sports medicine (Auckland, N.Z.)
|January 10, 2025
概括
与老年人相比,主体运动员的终身炼可能会减少炎症标志物,如C-反应蛋白,并增加互白素-10. 然而,它可能无法完全抵消在年轻人身上出现的与年龄相关的炎症变化.
科学领域:
- 老年学是一门学科.
- 运动生理学 运动生理学
- 免疫学 免疫学 免疫学
背景情况:
- 衰老与慢性低度炎症有关,增加疾病风险.
- 长期炼可以减少炎症,但减轻炼可能会扭转益处.
- 运动大师,终身运动者,可以提供关于持续抗炎作用的见解.
研究的目的:
- 系统地比较运动大师,未经训练的中年/老年人和年轻人的炎症概况.
- 为了确定终身运动是否可以完全抵消与年龄相关的炎症.
- 阐明持续训练对整个生命周期的炎症标志物的影响.
主要方法:
- 按照PRISMA指南进行系统审查,在PROSPERO.中注册.
- 包括比较主体运动员和未经训练的对照组的基线炎症标志物的研究.
- 对炎症标志物标准化平均差异 (SMD) 的元分析,根据运动类型/强度和性别对子组进行分析.
主要成果:
- 主体运动员表现出较低的C-反应蛋白和更高的互白素-10比未经训练的老年人.
- 主体运动员和未经训练的老年人之间瘤亡因子-α (TNF-α) 没有显著差异.
- 主体运动员仍然表现出较高的TNF-α和IL-6 (IL-6),与未经训练的年轻成年人相比,IL-10较低.
结论:
- 主体运动员与年龄相匹配的未经训练的同龄人相比,可能具有抗炎特征.
- 终身运动可能无法完全缓解所有与年龄相关的炎症变化.
- 需要进一步的研究来了解持续炼的长期炎症影响.
更多相关视频
10:19Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
Published on: August 22, 2014
14.2K
07:52Assessment of Murine Exercise Endurance Without the Use of a Shock Grid: An Alternative to Forced Exercise
Published on: August 14, 2014
19.1K
相关概念视频
01:19The Effect of Aging on Tissues
2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
01:26Aging
36
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
36
01:20Exercise and Cardiovascular Response
727
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
727
01:28Inflammatory Response
1.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.8K
01:37Mitochondria
10.5K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
10.5K
02:20Longitudinal Research
11.8K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
11.8K