对于T1b结直肠癌的内镜下膜剖析的长期结果
Zhixin Cao1, Jingfang Zhao2, Juan Liu2
1Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P. R. China.
Journal of cancer research and therapeutics
|January 10, 2025
概括
内镜下粘膜切割 (ESD) 对T1b结肠直肠癌 (CRC) 有效. 虽然淋巴结转移很罕见,但患者的特征应指导ESD后进行额外手术的决定,以获得最佳的结果.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 结肠直肠癌研究研究
背景情况:
- 膜下粘膜切割 (ESD) 是用于膜内和微侵袭性膜下结直肠癌 (CRC) 的标准.
- 对于T1bCRC (粘膜下侵袭深度≥1,000μm) 的ESD疗效需要进一步研究.
研究的目的:
- 评估ESD对T1b CRC的长期安全性和有效性.
- 为了比较单独使用ESD治疗的患者与手术后ESD治疗的患者之间的结果.
主要方法:
- 一组50名T1bCRC患者接受了ESD.
- 患者被分为单独ESD组 (n=19) 和ESD+手术组 (n=31).
- 评估了临床结果,淋巴结转移率 (LNM),复发率和存活率.
主要成果:
- 在所有患者中实现了En-bloc切除;在41例中实现了R0切除.
- 观察到6%的低LNM率,与高度瘤芽和入侵深度>1,500μm显著相关.
- 单独使用ESD和ESD+手术组之间的复发或生存率没有显著差异,尽管后者没有不良事件.
结论:
- ESD显示了低淋巴结转移率,是T1b CRC的安全,有效的治疗方法.
- 个体患者的特征对于确定需要进行ESD后手术干预至关重要.
- 根据ESD结果,进一步的研究可能会完善T1b CRC的治疗算法.
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