以前的短期不使用决定了肌肉基因表达和对随后的抵抗运动生理适应
Martino V Franchi1,2, Julián Candia3, Fabio Sarto1
1Department of Biomedical Sciences, University of Padova, Padova, Italy.
The Journal of physiology
|January 10, 2025
概括
短期的肌肉卸载会导致显著的力量和肌肉损失. 抵抗训练有效地恢复了肌肉功能和质量,增强了氧化代谢和缓慢的纤维类型适应.
科学领域:
- 运动生理学 运动生理学
- 肌肉生物学 肌肉生物学
- 分子适应 分子适应
背景情况:
- 短期的肌肉卸载 (例如,受伤后,住院) 会导致肌肉缩和衰弱.
- 随后的运动对卸载诱导的肌肉损失的恢复的影响还没有得到充分的研究.
研究的目的:
- 调查在短期单方面下肢悬浮 (ULLS) 后对抵抗训练 (RT) 的功能和分子适应.
- 确定恢复机制是否是卸载诱导变化的直接逆转.
主要方法:
- 11名男性接受了10天的ULLS,随后是21天的膝盖延伸器RT.
- 评估膝盖延伸器最大自愿收缩 (MVC),四头肌体积,肌肉纤维特征,糖原含量,SDH活性,线粒体蛋白质和基因表达.
主要成果:
- ULLS导致四头肌体积和MVC显著下降.
- RT完全恢复了MVC,并显著增加了四头骨体积.
- RT增加了糖原含量,全身水分,I型肌肉纤维和SDH活动.
- 线粒体融合/裂变蛋白 (MFN1,MFN2,OPA1,DRP1) 的增加,氧化酸化通路的上调.
结论:
- 抵抗训练在短期卸载后成功恢复肌肉功能和结构.
- 卸载后对RT的适应显示出增强的氧化代谢和缓慢的纤维类型,与典型的RT反应不同.
- 先前的肌肉卸载可能会影响后续抵抗训练的特定分子适应.
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