在怀孕期间在双极性障碍中使用长效注射性阿里皮普拉的治疗:一个范围审查
Andreea Teodorescu1,2, Lorena Dima1, Paula Simina Petric1,2
1Faculty of Medicine, Transilvania University of Brasov, Brasov, Romania.
American journal of therapeutics
|January 10, 2025
概括
关于在怀孕期间治疗双相情感障碍的长效注射性阿里皮普拉安全性的数据有限. 进一步的研究至关重要,以确定其有效性,并指导孕妇的治疗决策.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 生殖健康 生殖健康
背景情况:
- 在怀孕患者中治疗双相情感障碍带来了挑战,特别是关于抗精神病药物的安全性.
- 长效注射 (LAI) 抗精神病药物,如阿里皮普拉,越来越多地使用,但怀孕数据有限.
- 关于怀孕期间第二代抗精神病药物的证据很少;LAI aripiprazole数据甚至更有限.
研究的目的:
- 在患有精神疾病的患者怀孕期间使用阿里皮普拉的范围审查.
- 检查与怀孕期间服用阿里皮普拉相关的孕产妇,胎儿和新生儿结局.
主要方法:
- 按照PRISMA-ScR指南进行了系统范围审查.
- 在多个电子数据库中搜索了2008年1月至2024年2月期间发表的研究.
- 包括的研究集中在怀孕期间对阿里皮普拉的使用,并报告了相关的健康结果.
主要成果:
- 审查确定了11份符合纳入标准的案例报告.
- 还包括了四项额外的研究,包括前性和后性队列研究.
结论:
- 有限的数据需要进一步的研究来证实LAI aripiprazole在怀孕中的安全性和有效性.
- 由于未知的风险和益处,个性化治疗计划和知情决策至关重要.
- 需要更多的研究来指导在孕妇中使用LAI抗精神病药物治疗双相情感障碍.
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