相关实验视频

Updated: Jun 3, 2025

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

按需控制释放的多种药物输送系统,用于空间时间协同的抗瘤免疫疗法

Chenglin Liang¹, Hanxiao Yang¹, Tongtong Li¹

¹School of Pharmaceutical Sciences, Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou, 450001, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|January 10, 2025

概括

这项研究开发了一种工程细菌系统,通过促进细胞毒性T淋巴细胞 (CTLs) 透和按需释放PD-L1陷来增强癌症免疫疗法. 该系统使用温度敏感的纳米粒子在瘤微环境 (TME) 中精确地输送药物.

科学领域:

免疫治疗是一种免疫疗法.
生物医学工程生物医学工程
纳米技术纳米技术

背景情况:

细胞毒性T淋巴细胞 (CTLs) 的激活和PD-1/PD-L1阻断是癌症免疫治疗的关键策略.
在CTL激活和PD-1/PD-L1阻塞之间实现时空协同仍然是一个挑战.
目前的方法难以精确控制药物释放和免疫细胞向.

研究的目的:

设计一种基于细菌的传递系统,用于同时促进CTL透和按需释放PD-L1陷.
开发一种对温度敏感的系统,用于控制瘤微环境 (TME) 中的药物释放.
为优化癌症免疫疗法建立个性化管理方案.

主要方法:

携带具有光热转换能力的双重修饰的黑色素纳米粒子的工程细菌.
利用局部激光照射触发的特定温度进行药物释放.
根据TME变化和CTL透水平,开发了一个个性化的管理方案.

主要成果:

该系统成功地促进了CTL透,并在瘤部位控制了PD-L1陷释放.
双重修饰的纳米颗粒充当了供热和免疫激活的现场储存器.
个性化的激光照射触发了PD-L1陷的产生,恰恰是在CTL达到TME的峰值水平时.

结论:

工程细菌系统为优化癌症免疫治疗提供了一个灵活的平台.
使用这种新型的输送系统,可以实现对免疫疗法组件的时空控制.
这种方法有望通过同步免疫反应来提高治疗疗效.

关键词:

激活CTLs的激活方式根据需要释放PD-L1陷.muti-drugs 药物交付方式在空间时间上协同发挥作用.

更多相关视频

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models

Published on: August 16, 2010

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Drug Delivery: Miscellaneous Routes

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...