肠道微生物群因衰老而发生的变化会损害宿主的抗菌防御能力
Peng Gu1,2, Rongjuan Wei2, Ruofan Liu2
1Department of Critical Care Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|January 10, 2025
概括
老龄化减少了肠道细菌Parabacteroides goldsteinii,增加了感染风险. 补充P. goldsteinii或其化合物apigenin可以增强老年人的免疫反应和细菌清除.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 老年学是一门学科.
背景情况:
- 老年人对细菌感染的易感性和死亡率增加.
- 这种增加的脆弱性的确切原因仍然不完全理解.
- 肠道微生物群的改变越来越多地与与年龄相关的健康状况下降有关.
研究的目的:
- 为了研究开始性细菌在与年龄相关的细菌感染易感性中的作用.
- 确定肠道微生物群影响宿主衰老防御的机制.
- 探索潜在的治疗点,以改善与年龄相关的免疫功能障碍.
主要方法:
- 对老年和年轻小鼠以及老年人类肠道微生物组合的比较分析.
- 在老年小鼠中,用Parabacteroides goldsteinii进行殖民实验.
- 代谢分析,以确定保护性化合物.
- 分子测试以阐明已识别的化合物的作用机制.
- 使用细菌同源重组的基因鉴定.
主要成果:
- 老龄化与小鼠和人类的Parabacteroides goldsteinii减少有关.
- 与活生生的P. goldsteinii殖民保护老年小鼠免受细菌感染.
- 黄金石会产生apigenin,它可以纠正老老鼠的细菌清除缺陷.
- 原蛋白直接与Fgr激酶相互作用,通过Cdc42/Rac1通路增强巨细胞消化.
- 鉴定出AMPB基因对于P.goldsteinii.中的阿皮基因合成至关重要.
结论:
- 在衰老中减少P.goldsteinii有助于细菌防御功能受损.
- 由肠道微生物群衍生出来的化合物apigenin可以恢复与衰老相关的抗菌免疫力.
- 微生物-原蛋白-Fgr信号轴为提高老年人免疫力提供了一个新的治疗策略.
相关概念视频
Factors Affecting the Risk of Infection
11.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.3K
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Defense Mechanism Against Infection
6.4K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
6.4K
Bacterial Flora of the Large Intestine
377
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
377
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
107
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
107
Anatomy of the Intestines
71.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.3K


