在接受PICC手术的血液病患者中分析术后血栓形成的危险因素
Meifang Chang1, Xiaming Zhu, Minghong Liu
1Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, China.
Medicine
|January 10, 2025
概括
这项研究确定了在外围插入中央导管 (PICC) 放置后在血液病患者中预测血栓形成的关键因素. 导管感染,糖尿病和特定的血液标记物,如FDP和D-二次体增加了血栓形成的风险.
科学领域:
- 血液学 血液学 血液学
- 血管外科 血管外科
- 在瘤学瘤学.
背景情况:
- 周边插入的中央导管 (PICC) 对血液病患者至关重要.
- 在这个人群中,PICC插入后,血栓形成是一个显著的并发症.
- 确定预后因素对于风险分层和预防至关重要.
研究的目的:
- 分析PICC手术后血液病患者血栓形成的预后因素.
- 确定独立的风险因素,并建立血栓形成的预测值.
主要方法:
- 对223名接受PICC安置的血液病患者的回顾性分析.
- 单变量和多变量逻辑回归以确定影响因素.
- 接收器运行特征 (ROC) 曲线分析以确定预测值.
主要成果:
- 在223名患者中,有107名患者在PICC后发生了血栓形成.
- 确定了独立的危险因素:导管感染,糖尿病,血栓形成史,纤维素降解产物 (FDP) 升高,抗血III (AT-III) 低,D-二次数升高.
- 对于FDP,AT-III和D-二次体的AUC值分别为0.744,0.651和0.595.
结论:
- 导管感染,糖尿病,先前的血栓形成史,FDP>3.24 mg/L,AT-III<93%或D-二次体>2.41 μg/mL与PICC后的血栓形成风险增加有关.
- 这些因素可以帮助预测和潜在地预防高风险的血液病患者的血栓形成.
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