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Updated: May 11, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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发现了新型小分子抑制剂,破坏了MTDH-SND1蛋白质-蛋白质相互作用

Hao Shen1,2,3, Jiayu Ding1,2,3, Jiaying Ji1,2,3

  • 1State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.

Journal of medicinal chemistry
|January 10, 2025
PubMed
概括

研究人员开发了一种新型小分子C19,可以有效地抑制对乳腺癌生长至关重要的MTDH-SND1蛋白-蛋白相互作用 (PPI). 在临床前模型中,C19通过准这一关键相互作用来治疗乳腺癌,显示出有前途的潜力.

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Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b10:20

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A High-Throughput Enzyme-Coupled Activity Assay to Probe Small Molecule Interaction with the dNTPase SAMHD108:17

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相关概念视频

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...