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Updated: Jun 3, 2025

Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells
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Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells

Published on: June 10, 2022

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特殊的摄入量,有限的蛋白质表达:肝脏巨细胞在合成mRNA的翻译中丢失

Cheng Lin1,2, Adrian Kuzmanović1, Nan Wang1,3

  • 1Department of Internal Medicine III, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|January 10, 2025
PubMed
概括

合成的mRNA在像库普费尔细胞这样的肝脏非辅酶细胞 (NPC) 中表现不佳. 细胞差异,特别是肝细胞中的多化,解释了这一局限性,影响了基因治疗的交付.

关键词:
肝细胞 肝细胞 肝细胞脂质纳米颗粒的使用方法其他非对酶体细胞.普洛伊迪 (Ploidy) 是一个平的人.这是一种合成的mRNA.

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