重组人体生长激素对严重神经外科患者的影响:单一中心,回顾性研究
Xixian Liao1, Haorun Huang1, Binghui Qiu1
1Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
PloS one
|January 10, 2025
概括
重组人体生长激素 (r-hGH) 在重度神经外科手术患者的治疗改善了免疫细胞的数量,并减少了感染治愈时间. 虽然没有显著影响整体预后得分,但r-hGH在控制炎症反应方面表现出好处.
科学领域:
- 神经外科 神经外科
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 严重的神经外科手术的患者往往会经历炎症升高和免疫失调.
- 增长激素疗法正在探索其潜在的免疫调节和恢复作用.
研究的目的:
- 研究复合人体生长激素 (r-hGH) 对炎症标志物,免疫细胞种群和重症神经外科重症监护室 (NSICU) 患者的患者结局的影响.
主要方法:
- 从2020年8月到2021年6月,对236名NSICU患者进行了回顾性分析.
- 患者被分为复合人体生长激素 (GH) 组 (n=97) 和非GH (nGH) 组 (n=139).
- 评估CD4+T细胞计数,炎症调解剂 (IL-6,IL-10) 和格拉斯哥结局量表 (GOS) 的评分.
主要成果:
- 与nGH组相比,GH组的肺炎和内感染治愈时间显著缩短.
- 在GH组中观察到CD4+和CD8+T细胞计数显著增加.
- 在多个时间点之间检测到IL-6和IL-10水平的显著差异,表明炎症反应的调节.
结论:
- 重组人体生长激素 (r-hGH) 在严重的神经外科手术患者的应用有效地提高CD4+T细胞数量,并调节炎症介质.
- r-hGH治疗加速了感染的消失,包括肺炎,内和尿路感染.
- 虽然整体预后得分没有显著差异,但观察到的免疫调节和抗感染作用表明r-hGH在这个患者群体中的潜在益处.
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