术后预防性抗生素与耳植入后严重感染之间的关联:回顾性队列研究
Thomas Hudlebusch Meldgaard1, Martin Abou Taha, Christian Emil Faber
1Department of ORL-Head & Neck Surgery and Audiology, Odense University Hospital, Odense C, Denmark.
概括
手术后的抗生素预防没有显著影响耳植入术后的感染风险. 然而,在不服用抗生素的患者中,感染更频繁,这表明尽管统计学非显著,但潜在的益处.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 外科手术的结果
背景情况:
- 耳植入是恢复听力的一种常见程序.
- 手术后感染可能导致严重的并发症,包括植入物扩张和住院治疗.
- 术后延长的抗生素预防在预防这些感染中的作用仍在争论中.
研究的目的:
- 评估术后口服抗生素预防与需要住院治疗或在耳植入物手术后进行扩张的感染发生率之间的关联.
- 为了比较接受和没有接受术后抗生素预防的患者之间的感染率和扩散风险.
主要方法:
- 在2010年至2022年期间,在高等医疗机构接受耳植入手术的927名成年患者进行了回顾性队列研究.
- 患者被分为两组:接受4-10天术后口服抗生素的患者 (n=526) 和不接受预防的患者 (n=401).
- 分析了医疗记录,以比较感染率,扩散率和基线特征.
主要成果:
- 总体而言,3.0%的患者患有感染,需要住院治疗或实验 (1.4%的实验).
- 抗生素预防组的感染率为2.9%,而无预防组的感染率为3.2% (OR1.2,p=0.646).
- 之前接受过耳部外科手术 (7.7%) 和慢性耳炎 (16.7%) 的患者的严重感染率显着更高.
结论:
- 手术后的抗生素预防与感染风险降低并没有显著相关,导致住院或扩张.
- 尽管统计不显著,但在没有接受抗生素预防的患者中,感染率在数值上更高.
- 患有耳部外科手术或慢性耳炎病史的患者有较高的严重术后感染风险.
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