相关实验视频
Updated: Jun 3, 2025
08:40
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
7.0K
沙门氏菌感染加速了肠道上皮的产后成熟
Stefan Schlößer1, Anna-Lena Ullrich1, Nastaran Fazel Modares1,2
1Institute of Medical Microbiology, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen 52074, Germany.
概括
沙门氏菌感染加速新生儿肠道成熟,过早引入成人特征. 免疫媒介,特别是像IL-22这样的细胞因子,驱动这种重编程,破坏正常发育.
科学领域:
- 免疫学 免疫学 免疫学
- 发展生物学 发展生物学
- 微生物学 微生物学
背景情况:
- 产后发育涉及肠道代谢,宿主微生物和免疫系统的精确调节.
- 新生儿肠道平衡对于长期健康和适应至关重要.
研究的目的:
- 为了研究 *Salmonella* Typhimurium 感染对新生儿肠道上皮质成熟的影响.
- 为了识别免疫细胞衍生介质,参与感染诱导的组织重编程.
主要方法:
- 利用有条件的Myd88缺乏的小鼠来研究免疫反应.
- 在细胞因子刺激实验中使用新生儿肠道上皮干细胞器官.
主要成果:
- 沙门氏菌感染加快了新生儿上皮质的成熟,诱导了过早的成人类抗菌,代谢,发育和再生特征.
- 细胞因子刺激显示出协同作用和对抗作用,IL-22,IL-4/IL-13,TNF和IL-6显著促进了肠细胞重编程.
- 免疫细胞激活扰乱了生理学产后组织成熟.
结论:
- 与感染相关的免疫激活会改变新生儿肠道正常发育.
- 这种干扰可能会对临床结果和过渡到成年期产生负面影响.
更多相关视频
08:50A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
3.7K
08:15Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids
Published on: November 15, 2019
6.0K
相关概念视频
01:23Renewal of Intestinal Stem Cells
2.5K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.5K
01:23Anatomy of the Intestines
71.3K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.3K