在吸入的鼻氧化物中Xylometazoline诱导的变化检测了阻塞的鼻骨
Pekka Tamminen1,2,3,4, Ilkka Kivekäs1,2, Jura Numminen2
1Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön Katu 34, 33520 Tampere, Finland.
Journal of breath research
|January 10, 2025
概括
鼻氧化物 (nNO) 水平及其对西洛梅塔林的反应可以帮助确定慢性鼻炎 (CRS) 患者的鼻骨状况. 这种诊断方法是有效的,无论使用皮质类固醇.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 呼吸系统医学 呼吸系统医学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 慢性鼻炎 (CRS) 与不同的鼻氧化 (nNO) 水平有关,可能与鼻骨通透性有关.
- 了解nNO,骨质状况和对脱凝剂的反应之间的关系对于CRS管理至关重要.
研究的目的:
- 为了调查nNO水平和对西洛美zoline的反应是否不同,在CRS患者中开放或阻塞的鼻骨.
- 评估局部用西洛梅塔佐林和鼻腔内皮质类固醇对CRS患者nNO测量的影响.
主要方法:
- 66名CRS患者和23名对照人使用EcoMedics CLD 88p分析仪测量了鼻氧化物 (nNO).
- 在施用西洛梅他林之前和之后进行了测量,分别进行了三次检查:在服用药物之前,在服用药物暂停后和在使用酸后.
- 在每次访问时,使用圆束计算机断层扫描 (CBCT) 评估骨阻塞.
主要成果:
- 最低的nNO度在CRS患者中观察到,这些患者骨受阻.
- 在骨开放的患者中,西洛梅塔佐林显著降低了nNO,但对骨受阻的患者没有显著影响.
- 在开放和阻塞骨组之间,西罗梅塔林诱导的nNO变化之间的差异在所有访问中都是统计学上显著的.
结论:
- 在CRS患者中,原生的nNO水平和施用西洛梅塔佐林后的nNO变化可以有效地区分开放和受阻的鼻骨.
- 这种评估骨阻塞的方法是可靠的,不管同时使用局部皮质类固醇治疗.
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