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在大鼠中评估生物活性植物化学物Withanone的临床前药理动力学,绝对生物可用性和剂量比例

Sandeep K Singh1, Mamunur Rashid2, Swati Chaturvedi3

  • 1Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India; Department of Pharmacy Practice and Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

Bioorganic chemistry
|January 10, 2025
PubMed
概括

维他 (WN) 在老鼠中表现出较差的口服吸收和较低的生物可用性,表明可和的药理动力学. 这些发现对于优化WN剂量及其潜在的治疗开发至关重要.

关键词:
生物分析生物分析生物可用性 生物可用性剂量相称性 剂量相称性药理动力学 药理动力学这种植物是Withhania somnifera.在Withhanone没有一个.

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