在过敏性鼻炎中,PD-1及其配体的遗传变异,基因-基因和基因-环境相互作用
Ruo-Xi Chen1, Zheng Luan1, Chong Shen2
1Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
在PDCD1LG1和PDCD1LG2中的遗传变异与过敏性鼻炎 (AR) 易感性有关. 这些编程细胞死亡1 (PD-1) 途径基因可能会影响AR发展中的基因-基因和基因-环境相互作用.
科学领域:
- 免疫遗传学 免疫遗传学
- 过敏学 过敏学
- 分子流行病学分子流行病学
背景情况:
- 过敏性鼻炎 (AR) 的病因涉及复杂的遗传和环境相互作用.
- 编程细胞死亡1 (PD-1) 和它的配体 (PD-L1,PD-L2) 调节与亚托皮性疾病相关的免疫和炎症反应.
研究的目的:
- 调查PD-1,PD-L1和PD-L2基因中的遗传变异与AR易感性的关联.
- 探索潜在的基因-基因和基因-环境相互作用在AR的发病过程中.
主要方法:
- 一项基于医院的病例控制研究包括452名AR患者和495名对照.
- 在PDCD1,PDCD1LG1和PDCD1LG2中的八个单核酸多态 (SNPs) 被基因型化.
- 用基因表达数据和eQTL分析来探索调节机制.
主要成果:
- PDCD1LG1 rs2297136的多态性与AR风险增加有关.
- PDCD1LG2 rs16923189的多态性与AR风险降低有关.
- 观察到基因与环境因素 (如烟雾,烟) 之间的相互作用,但经过校正后没有统计学意义.
结论:
- 在PDCD1LG1和PDCD1LG2中的特定SNP与研究中中国人口的AR易感性有关.
- PD-1/PD-L1和PD-1/PD-L2信号通路可能在AR病变发生过程中扮演中介基因-基因和基因-环境相互作用的角色.
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