高暴露与血清脂质代谢的调节有关
Yong Tan1, Zixiong Zhang1, Jinru Yang2
1Hubei Selenium and Human Health Institute, the Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, China; Hubei Provincial Key Lab of Selenium Resources and Bioapplications, Enshi 445000, China.
高 (Se) 暴露与血清脂质水平的降低以及成年人患脂质障碍症的风险降低有关. 这项研究使用代谢学分析探索了和脂质代谢之间的关联.
科学领域:
- 环境健康 环境健康
- 代谢学 代谢学 代谢学
- 人体生理学 人体生理学
背景情况:
- (Se) 暴露与人类血清脂质代谢之间的关系尚未得到充分证实.
- 高Se暴露对脂质标记物,脱脂症和非酒精性脂肪性肝病 (NAFLD) 的影响需要进一步调查.
研究的目的:
- 为了研究高暴露和成人血清脂质代谢之间的横截面关联.
- 为了确定特定的脂质代谢物和受暴露影响的途径.
主要方法:
- 使用液体染色学/质谱学 (LC/MS) 的血清非向代谢学分析.
- 在高Se暴露和对照组之间比较脂质特征 (胆固醇,LDL-C,HDL-C,APOB).
- 血清Se水平和脂质代谢物之间的相关性分析.
主要成果:
- 确定了144种不同的途径和204种不同丰富的代谢物,包括32种脂质代谢物.
- 与对照组相比,高Se暴露组的TG,LDL-C,HDL-C和APOB水平显著不同 (p <0.05).
- 在血清Se和胆固醇 (CHOL) 之间观察到显著的负相关性 (r = -0.201,p < 0.01).
结论:
- 高暴露与血清脂质样本有负面关联.
- 高暴露可能会降低高总胆固醇和HDL-C脂质不良症的风险.
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