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Updated: Jun 3, 2025

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基于阿司匹林的PROTAC作为抗炎作用的COX-2降解剂

Xuan-Jie Yu1, Li-Li Chen2, Zhi-Jie Ren3

  • 1College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China; Institute for Inheritance-Based Innovation of Chinese Medicine, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, China.

Bioorganic & medicinal chemistry
|January 10, 2025
PubMed
概括

研究人员开发了基于阿司匹林的新型PROTAC来降解关键炎症酶环氧化酶-2 (COX-2). 这些降解剂通过无素-蛋白酶体通路有效向COX-2,提供新的抗炎药物见解.

关键词:
这是一种抗炎症药物.亚司匹林是一种阿司匹林.循环氧基因酶-2 的作用.降解降解是一种降解.蛋白质溶解的目标是喜马拉.

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