[大黄和出血风险,关于一个案例]
Imene Beghriche1, Abdelaali Belhachem2, Imene Hamidene1
1Laboratoire centrale de l'établissement hospitalier Didouche Mourad, Constantine, Algérie; Université constantine 3, faculté de médecine, Algérie.
概括
传统使用的香和白注水可以危险地增加抗凝剂 (阿诺库马罗尔) 水平,增加出血风险. 监测植物药物相互作用至关重要,特别是在依赖草药和传统医学的群体中.
科学领域:
- 药理学 药理学是指药理学的学科.
- 民族植物学 民族植物学
- 临床毒理学 临床毒理学
背景情况:
- 在阿尔及利亚,用于治疗各种疾病的药用植物是常见的.
- 植物药物相互作用可以改变药物的疗效,引起毒性或导致治疗失败.
- 像维生素K对抗剂这样的抗凝剂具有狭窄的治疗范围,增加了相互作用风险.
研究的目的:
- 报告一种草药输液和阿诺库马罗尔之间的临床相互作用情况.
- 突出结合传统疗法与抗凝治疗的潜在危险.
- 强调需要在使用药用植物的人群中进行植物监测.
主要方法:
- 一个77岁的患者在治疗心房动时服用阿诺库马罗的案例研究.
- 在食用草药茶前后监测国际规范化比率 (INR) 和前血红素时间 (PT).
- 基于 Oregano 和 Verbena 的植物化学成分,分析了潜在的相互作用.
主要成果:
- 患者的INR显著增加 (6.42) 后消费菜和维维纳注射.
- 停止使用草药茶导致INR正常化,随后在适度摄入后稳定.
- Oregano 和 verbena 含有抑制 CYP 450 酶 (CYP 2C9,CYP 3A4) 的多和素,增加了阿诺库马罗尔水平.
- Oregano 也拥有固有的抗凝固特性,由于卡尔瓦克罗尔和蒂摩尔.
结论:
- 菜/菜和阿诺库马罗之间存在显著的相互作用,增加出血风险.
- 药用植物的传统用途需要识别和监测不良影响和药物相互作用.
- 国家植物监测计划对于管理传统医疗实践中草药相关风险至关重要.
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