相关实验视频

Updated: Jun 3, 2025

Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model

Intracranial Subarachnoidal Route of Infection for Investigating Roles of Streptococcus suis Biofilms in Meningitis in a Mouse Infection Model

Published on: July 1, 2018

对使用全基因组测序的猪生产系统中Streptococcus suis流行病学的新见解

Anna Vilaró¹, Kasper T Karstensen², Laia Serra¹

¹Grup de Sanejament Porcí (GSP), Partida Caparrella 97C, Lleida 25192, Spain.

Veterinary microbiology

|January 10, 2025

概括

在西班牙,使用全基因组测序研究了具有动物感染潜力的猪病原体Streptococcus suis. 血清型9和ST123是最常见的,检测到广泛的耐药基因,如tet(O) 和erm(B).

科学领域:

兽医微生物学兽医微生物学
基因组学就是基因组学.
流行病学流行病学

背景情况:

瑞士杆菌 (S. suis) 是一种重要的猪病原体,造成经济损失,并对人类构成动物感染风险.
了解S. suis的遗传多样性和抗菌素耐药性对于兽医和公共卫生管理至关重要.

研究的目的:

从西班牙猪中分离出S. suis的遗传特征,包括血清型,序列类型 (ST),以及抗菌素耐药性 (AMR) 和毒性基因.
调查S. suis在集成猪生产系统中的垂直传播模式.

主要方法:

全基因组测序 (WGS) 在2018年至2022年期间从临床猪样本中收集的154个S. suis分离物上进行.
分析包括识别血清型,ST,AMR基因和病毒性相关基因.
遗传学分析被用来探索传播途径和农场起源之间的关联.

主要成果:

血清型9主要与ST123相关,是发现的最常见的血清型.
观察到抗微生物耐药性基因 (tet(O) 和 erm(B) 的高患病率,分别对四环素和宏化物产生耐药性.
关键毒性基因 (EPF,MRP,SLY) 的变异性存在和对测试的抗微生物药物具有低至高的表型耐药性,对多西环素和三甲-硫甲醇具有高耐药性.

结论:

该研究提供了西班牙猪群中S. suis的关键流行病学数据,突出了9/ST123血清型作为主导血统.
了解样本的来源,例如祖母和母母母猪场,对于有效的疾病管理和抗菌药物管理至关重要.
通过WGS进行遗传表征对于追踪S. suis和在动物和公共卫生环境中告知控制策略至关重要.

关键词:

抗微生物敏感性抗微生物敏感性流行病学流行病学猪生产系统生猪生产系统这是一种Streptococcus suis.整个基因组的测序.

更多相关视频

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

Published on: December 23, 2022

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood

Published on: November 28, 2018

相关概念视频

Viral Recombination

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.

Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...