孕产妇产前和产后压力以及孕产妇和婴儿肠道微生物群的特征
Henrik Eckermann1, Hellen Lustermans1, Katariina Parnanen2
1Radboud university medical center, Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Nijmegen, the Netherlands.
Psychoneuroendocrinology
|January 10, 2025
概括
母亲的压力会影响母亲和婴儿的肠道微生物群,影响微生物的多样性和组成. 这项研究突出显示,母亲的压力与婴儿肠道微生物群的挥发性之间存在着一致的积极联系.
科学领域:
- 微生物组研究的研究.
- 孕产妇和儿童的健康
- 心理神经免疫学 心理神经免疫学
背景情况:
- 孕产妇的压力对孕产妇和婴儿的心理健康构成风险.
- 肠道微生物群可能会调解压力效应.
- 以前的研究表明,压力和肠道微生物变化之间存在联系.
研究的目的:
- 为了研究孕期和产后母亲微生物群的变化.
- 检查母亲的压力和母亲/婴儿肠道微生物群之间的关联.
- 假设的压力增加了微生物群的挥发性,并改变了特定的细菌群.
主要方法:
- 在多个时间点收集母亲和婴儿便样本.
- 采用了枪元基因组测序来进行微生物群分析.
- 通过自我报告和头发皮质醇/皮质素水平测量母亲的压力.
主要成果:
- 产后母亲的微生物群组成发生了显著的变化.
- 确定了应激措施与母亲/婴儿微生物群多样性和丰度之间的关联.
- 孕产妇的压力评分和头发皮质醇/皮质与婴儿微生物群的挥发性正相关.
结论:
- 孕产妇产前和产后压力与孕产妇和婴儿肠道微生物群有关.
- 关联是特定于时间点的,并非在所有微生物特征中均.
- 在母亲的压力和婴儿微生物群的挥发性之间发现了一致的正相关性,值得进一步调查.
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