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PTEN rs701848作为乳腺癌预测标志物的临床影响

Basma El-Sayed Fotouh¹, Mai Abd El-Meguid¹, Ghada Maher Salum¹

¹Department of Microbial Biotechnology, Biotechnology Research Institute, National Research Centre, Dokki, P.O. 12622, Giza, Egypt.

Clinical biochemistry

|January 10, 2025

概括

患有PTEN rs701848T/C遗传变异的乳腺癌风险增加. 随着疾病的进展,PTEN蛋白水平显著下降,这表明它有可能成为乳腺癌的预测标志物.

科学领域:

在瘤学瘤学.
遗传学是一个遗传学.
分子生物学分子生物学

背景情况:

乳腺癌 (BC) 发病率在全球范围内不断上升,使其成为女性最常见的恶性瘤.
PTEN (酸酶和张素同类物) 通过抑制PI3K/AKT通路而起瘤抑制作用.
了解PTEN的遗传变异对于BC研究至关重要.

研究的目的:

研究PTEN rs701848T/C遗传变异与乳腺癌进展之间的关联.
为了评估乳腺癌患者的PTEN蛋白水平.
探索PTEN作为乳腺癌预测生物标志物的实用性.

主要方法:

用生物信息分析来研究PTEN rs701848T/C多态性.
用qRT-PCR对100名埃及BC患者和50名健康对照进行基因型鉴定.
通过ELISA量化PTEN蛋白水平,与临床数据相关.

主要成果:

在乳腺癌患者中,PTEN rs701848T/C的TC基因型显著更频繁 (p=0.03).
携带TC的患者表现出晚期瘤阶段,更大的瘤大小和转移的风险增加.
PTEN蛋白水平显著下降,与疾病进展和诊断准确性相关.

结论:

PTEN rs701848T/C多态性与增加乳腺癌风险和进展有关.
降低的PTEN蛋白水平与晚期疾病阶段有关.
作为乳腺癌的基因组和蛋白质组水平的预测生物标志物,PTEN具有前景.

关键词:

乳腺癌乳腺癌乳腺癌基因多态化是基因的多态化.在这里,我们可以使用PTEN.预测性生物标志物预测性生物标志物一个进步的进步.

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