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贾威埃尔米颗粒 (JWEMGs) 清除了持续的HR-HPV感染,尽管改善了阴道微生态

Xiu Li¹, Li Ning¹, Hongting Zhao²

¹The First Clinical Medical School, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, China; Jiangsu Clinical Medicine Innovation Center for Obstetrics and Reproduction, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, China.

Journal of ethnopharmacology

|January 10, 2025

概括

贾威埃尔米颗粒 (JWEMGs) 通过恢复乳杆菌和激活ALPK1/NF-κB通路,改善阴道微生态,清除高风险的人类乳头瘤病毒 (HR-HPV) 感染. 这种传统的中医药增强了粘膜免疫力,调节了阴道微生物群.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

贾威埃尔米颗粒 (Jiawei Ermiao Granules,简称JWEMGs) 是一种传统的中国草药配方,用于治疗人类乳头瘤病毒 (HPV) 感染.
对于JWEMG的抗病毒机制,特别是关于阴道微生态的抗病毒机制,人们还不太了解.

研究的目的:

研究JWEMG如何调节阴道微生态和清除HPV感染.
阐明JWEMGs治疗效果的潜在分子机制.

主要方法:

用JWEMGs治疗的65名高风险HPV (HR-HPV) 患者的阴道微生态指标的临床评估.
从33名患者的阴道样本进行元基因组测序,以分析微生物组的变化.
使用HaCaT-HPV E6/E7细胞进行体外研究,以评估JWEMG对ALPK1表达和细胞因子分泌的影响.

主要成果:

JWEMGs显著改善了阴道清洁,pH,Nugent和Donders分数,并减少了炎症标志物.
治疗增加了乳酸菌 (特别是L.crispatus) 的丰度,减少了加德内雷拉菌,表明阴道微生物组更健康.
在实验室中,JWEMG促进了ALPK1的表达,并增强了IL-6,IL-8,TNF-α和化学分泌,激活了ALPK1/NF-κB通路.

结论:

在HR-HPV感染的个体中,JWEMGs有效地重塑阴道微生物群,并增强下生殖道的粘膜免疫力.
这些发现表明JWEMG激活ALPK1/NF-κB通路,促进细胞因子和化学因子表达以产生抗病毒作用.

关键词:

通过ALPK1/NF-κB通路.在HR-HPV感染中.贾威埃尔米亚颗粒粘膜免疫力粘膜免疫力阴道微生态阴道微生态

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