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Updated: Jun 13, 2025

Combining Non-reducing SDS-PAGE Analysis and Chemical Crosslinking to Detect Multimeric Complexes Stabilized by Disulfide Linkages in Mammalian Cells in Culture
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在BMP-9和BMP-10中的链间二硫化物键形成的分子基础

Tristin A Schwartze1, Stefanie A Morosky2, Teresa L Rosato2

  • 1Department of Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.

Journal of molecular biology
|January 10, 2025
PubMed
概括

骨形态遗传蛋白 (BMPs) 9和10对于血管发育至关重要. 这项研究揭示了几何应变,而不是囊化,限制了BMP-9/10二硫化物结合的二聚体形成,影响了信号传递和遗传性出血性telangiectasia.

关键词:
这是一架BMP-10战斗机.美国BMP-9战斗机在X射线晶体学.债券紧张关系紧张关系骨形态遗传蛋白质 骨形态遗传蛋白质双硫化物键是一种二硫化物键.辐射敏感度 辐射敏感度

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