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Updated: Jun 18, 2026

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在类风湿性关节炎中,TREM1通过E2F1介导的TOMM40转录轴干扰巨细胞菌

Zhen-Zhen Dai1, Jing Xu2, Qin Zhang2

  • 1Department of Pediatric Orthopedics, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Institute for Pediatric Research, Shanghai, China.

Free radical biology & medicine
|January 10, 2025
PubMed
概括

在类风湿性关节炎中,向质细胞1 (TREM1) 上表达的触发受体,使得巨细胞恢复了线粒和减少反应性氧物种 (ROS). 通过改善线粒体功能,抑制TREM1有效治疗实验性关节炎.

关键词:
在 E2F1/TOMM40 轴上巨细胞是一个巨细胞.线粒细胞衰变 - - 线粒细胞衰变 (mitophagy) 是一种类风湿性关节炎 类风湿性关节炎 类风湿性关节炎这就是TREM1的特点.

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