维生素D补充剂对TSH和甲状腺激素的影响:随机对照试验的系统审查
Sara Safari1, Sara Shojaei-Zarghani2, Roghayeh Molani-Gol1
1Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Nutrition Research Center, Department of Community Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Endocrinologia, diabetes y nutricion
|January 10, 2025
概括
维生素D补充剂通常对甲状腺激素,包括TSH,T4和T3水平没有显著影响. 需要进一步的高质量研究来证实这些发现,并探索其他甲状腺功能标志物.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 在全球范围内,甲状腺疾病影响着大约2亿人.
- 营养因素和甲状腺疾病之间存在已确定的联系.
- 维生素D是一种重要的营养素,在甲状腺功能中具有潜在的作用.
研究的目的:
- 系统地审查维生素D补充剂对甲状腺刺激激素 (TSH) 和甲状腺激素水平的影响.
- 综合了研究维生素D和甲状腺功能的随机对照试验 (RCT) 的研究结果.
主要方法:
- 在Web of Science,PubMed,Scopus和Google Scholar的综合文献搜索,直到2023年6月.
- 包括16个原始英语随机对照试验 (RCT).
- 分析了来自1127名参与者的数据 (630名干预,497名控制).
主要成果:
- 在56.2%的分析病例中,维生素D补充对血清TSH水平没有显著影响.
- 在26.6%的研究中观察到TSH水平升高,而18.7%报告TSH水平下降.
- 在大多数包含的RCT中,没有注意到对甲状腺素 (T4),三甲状腺素 (T3),自由T4 (fT4) 或自由T3 (fT3) 水平的显著影响.
结论:
- 目前的证据表明,维生素D补充对主要甲状腺激素水平和TSH的影响有限.
- 大部分研究没有发现维生素D对TSH,T4和T3有任何影响.
- 高质量的研究对于确定维生素D对甲状腺功能标记物的作用至关重要.
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