在西班牙一家医院中,中枢神经系统瘤幸存者的现状
Ivonne Marcela Rincón-Mantilla1, Blanca Herrero2, Elena Herranz Valero3
1Doctorado del Programa de Medicina, Universidad Autónoma de Madrid, Madrid, Spain; Departamento de Oncohematología Pediátrica, Hospital Universitario Niño Jesús, Madrid, Spain.
Anales de pediatria
|January 10, 2025
概括
中枢神经系统 (CNS) 瘤幸存者,特别是接受放射治疗 (RTx) 的人群中,长期的后遗症很常见. RTx显著影响适应性行为和社会结果,但不影响生活质量或自尊.
科学领域:
- 在瘤学瘤学.
- 神经科学是一个神经科学.
- 辐射疗法 辐射疗法
背景情况:
- 中枢神经系统 (CNS) 瘤影响幸存者长期 (LT) 后续影响生活的各个阶段.
- 了解这些晚期发病率对于改善幸存者护理和结果至关重要.
研究的目的:
- 评估晚期发病率,与健康相关的生活质量 (HRQoL),自尊,功能状态,适应性行为,体力活动和中枢神经系统瘤幸存者的社会结果.
- 评估放射治疗 (RTx) 对这些结果的长期影响的具体作用.
主要方法:
- 评估了111名中枢神经系统瘤幸存者,随访时间≥10年.
- 评估包括临床评估,SF-36 (HRQoL),罗森伯格自尊尺度,兰斯基/卡诺斯基尺度 (功能状态),Vineland-II尺度 (适应性行为),以及有关身体活动和社会变量的问卷.
主要成果:
- 最常见的LT后果是神经病 (55%),神经精神病 (53.1%),内分泌 (49.5%).
- 与非RTx幸存者相比,接受RTx治疗的幸存者 (n=52) 表现出较差的适应行为,教育成就和关系状况.
- 在RTx和非RTx组之间没有发现生活质量或自尊评分的显著差异.
结论:
- 中枢神经系统瘤的幸存者经历了长期后果的高患病率,特别是那些接受RTx治疗的人.
- 在这些幸存者中,RTx显著影响功能状态和社会结果.
- 长期来看,RTx对生活质量和自尊没有显著的影响.
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