帕克西林和约克之间的反循环维持了多索菲拉肠道平衡和再生
Dan Jiang1,2, Pengyue Li3, Yi Lu3
1The Department of Urology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, 200233, China.
Nature communications
|January 10, 2025
概括
帕克斯是一种同类于哺乳动物PXN的蛋白质,它调节了Drosophila肠道中的干细胞平衡. 它控制肠干细胞 (ISC) 的增殖和分化,影响组织稳态和再生.
科学领域:
- 发展生物学 发展生物学
- 干细胞生物学 干细胞生物学
- 分子生物学分子生物学
背景情况:
- 保持平衡的干细胞自我更新和分化对于组织平衡至关重要.
- 控制干细胞命运决定的精确机制尚未完全理解.
- 成人多索菲拉肠干细胞 (ISC) 为研究这些过程提供了一个模型.
研究的目的:
- 确定调节Drosophila.ISC增殖和分化的因素.
- 阐明已识别的因子Pax在中肠内静止和再生中的作用.
- 了解Pax影响ISC命运的分子机制.
主要方法:
- 在成年Drosophila肠干细胞 (ISCs) 中进行RNA干扰 (RNAi) 查.
- 在哺乳动物系统中分析Pax ortholog (PXN).
- 研究与Hippo信号通路组件 (Yki) 和Notch信号的相互作用.
主要成果:
- 帕克斯被认为是ISC扩散和差异化的关键调节者.
- 帕克斯的丧失导致ISC增多和差异化减弱成为吸收性肠球细胞 (ECs).
- 帕克斯作为Hippo路径的保存目标,与Yki相互作用以抑制ISC扩散.
- 通过激活Notch信号,Pax促进了ISC的差异化.
结论:
- 帕克斯是Drosophila中肠内静止和再生的关键调节者.
- 帕克斯集成Hippo和Notch的信号通道来控制ISC的命运.
- 帕克斯代表了一种维持组织维护和肠道功能的保存机制.
相关概念视频
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
Feedback Loops
55.9K
In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
55.9K
Interactions Between Signaling Pathways
6.2K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.2K
Overview of Regeneration and Repair
3.9K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Regeneration
All animals have varying degrees of...
3.9K


