LiWei囊在具有侵蚀性的慢性非缩性胃炎中的有效性和安全性:一项随机对照试验

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Danyang Cui^1,2, Xiao Geng¹, Juan Wang²

¹General Hospital of Northern Theater Command, No.83 Cultural Road, Shenhe District, Shenyang, 110016, Liaoning, China.

Scientific reports

|January 10, 2025

概括

李伟囊 (LWC) 在慢性非缩性胃炎患者中显著改善了表胃疼痛和膨胀. 这种传统中医治疗也促进了内镜侵蚀的愈合,显示出有希望的疗效和安全性.

科学领域:

胃肠病学胃肠病学
传统中国医学 (TCM) 是一种
药理学药理学是指药理学的学科.

背景情况:

具有侵蚀和湿热静止综合征的慢性非缩性胃炎 (CNG) 是一个治疗挑战.
传统中医的原则为管理复杂的胃肠道疾病提供了一种独特的方法.
评估像LiWei囊 (LWC) 这样的新型治疗药物对于改善患者的治疗结果至关重要.

研究的目的:

评估LiWei囊 (LWC) 治疗具有侵蚀性的慢性非缩性胃炎 (CNG) 的疗效和安全性.
根据传统中医 (TCM) 原则评估LWC的有效性,特别是对于湿热静止综合征.
在一项随机双盲试验中,将LWC与阳性对照 (Sanjiu Weitai Capsule) 和安慰剂进行比较.

主要方法:

进行了II期,多中心,随机,双盲,安慰剂和正控试验.
301名患有CNG和湿热静止综合征的参与者被分配到LWC,圣威台囊 (SJWT) 或安慰剂组.
治疗持续时间为4周,随后进行了16周的随访,评估了表胃疼痛/胀气治愈率的初级结果和包括内镜和组织病理改善在内的二级结果.

主要成果:

与SJWT (42.22%) 和安慰剂 (22.45%) (P < 0.001) 相比,LiWei囊 (LWC) 在表胃疼痛/膨胀 (76.84%) 的治愈率显著更高.
随着LWC治疗,内镜侵蚀愈合率 (65.3%) 与SJWT (46.7%) 和安慰剂 (30.6%) 相比更高 (P < 0.001).
该研究表明,在治疗和随访期间,LWC的安全性概况有利.

结论:

威囊 (LWC) 是有效和安全的缓解表胃疼痛/膨胀和促进内镜侵蚀愈合在CNG患者湿热静止综合征.
对于这种特定的患者群体来说,LWC显示出作为一个有前途的治疗选择的潜力.
进一步的研究可能会根据TCM原则验证LWC在治疗慢性胃炎中的作用.

关键词:

慢性非缩性胃炎慢性非缩性胃炎侵蚀侵蚀侵蚀侵蚀侵蚀随机对照试验是随机对照试验.传统的中国医学是传统的中国医学.

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