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口服结肠向的响应性基托/基纳米颗粒推动了托法西提尼布在结肠炎治疗中的应用

Chunfei Wu^1,2, Chuanlin Bi^3,4, Geun-Soo Kim²

¹Medical School, Qingdao Huanghai University, Qingdao, China.

Scientific reports

|January 10, 2025

概括

新的纳米粒子将托法西提尼布 (Tof) 直接输送到结肠,通过减少副作用来改善性结肠炎 (UC) 治疗. 这种有针对性的方法提高了Tof在管理中度至重度UC的疗效.

科学领域:

药理学药理学是指药理学的学科.
材料科学材料科学材料科学
胃肠病学胃肠病学

背景情况:

托法西替尼 (Tof) 治疗性结肠炎 (UC),但具有剂量依赖的全身副作用.
目前的治疗需要改善药物输送,以提高疗效和降低毒性.

研究的目的:

开发一种有效的口服结肠向药物输送系统,用于Tof.
通过使用pectin,chitosan,牛血清albumin和chondroitin硫酸盐构建ToF载荷的纳米粒子 (NP),用于向的UC治疗.

主要方法:

合成的Tof@BSA-Chs-CP纳米颗粒,具有pH敏感的pectin/chitosan外.
利用肠道微生物分泌的酶来触发结肠中的NP降解.
在小鼠结肠炎模型中评估NP性能.

主要成果:

果/花素外显示出pH敏感性质,降低了系统吸收并向炎症的结肠部位.
口服Tof@BSA-Chs-CP NPs有效地改善了小鼠的大肠炎.
NP治疗调节了促炎性细胞因子和免疫调节因子,加快了结肠炎的解决.

结论:

开发的Tof@BSA-Chs-CP NPs显示出对Tof.的向结肠输送有希望.
这种有针对性的输送系统提供了一种潜在的策略,可以改善中度至重度性结肠炎的TOF治疗,同时最大限度地减少全身副作用.

关键词:

药物输送的目标是结肠.酶触发释放的释放是由酶触发的释放.性结肠炎是一种对于pH值敏感的释放.

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