尿度与美国成年人结石发生可能性之间的关联:基于人口的研究
Dan Liang1, Chang Liu2, Mei Yang3
1Department of Endocrine, People's Hospital of Chongqing Liang Jiang New Area, Chongqing, China.
Scientific reports
|January 10, 2025
概括
尿水平升高 (ULL) 与美国成年人结石风险更高有关. 这项研究表明,尿液中度可能是结石发育的预后指标.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 毒理学 毒理学 毒理学
背景情况:
- 暴露对人类健康构成重大风险.
- 结石是一种普遍的疾病,具有多因素的原因.
- 暴露和结石风险之间的关系需要进一步阐明.
研究的目的:
- 调查尿水平 (ULL) 与美国成年人群中结石风险之间的关联.
- 探索ULL作为结石预测结果的潜在作用.
主要方法:
- 这是一项采用2007-2018年国家健康和营养检查调查 (NHANES) 数据的横截面研究.
- 使用加权多重逻辑回归分析来评估ULL和结石之间的相关性.
- 进行了子组分析和相互作用测试,以检查关联的一致性.
主要成果:
- 总共有8,325名参与者被纳入,结石的患病率为9.90%.
- 在较高的ULL和结石风险增加之间发现了统计学上显著的积极关联 (OR:1.07,95%CI:1.01-1.14,p=0.03).
- 在ULL的最高四分位数中,与最低四分位数的人相比,患结石的风险增加了64% (OR: 1.64,95%CI: 1.05-2.57,p=0.03).
结论:
- 这项研究表明,尿液度与患结石的风险之间存在正相关性.
- 尿中的含量可能对结石的结果具有预后价值.
- 需要进一步的前性研究来证实在病发病的作用,并验证ULL作为可靠的预测因子.
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