美国2型糖尿病的提尔泽帕提德使用者的特征和剂量模式
Reema Mody1, Karishma Desai2, Chia-Chen Teng2
1Eli Lilly and Company, Indianapolis, IN, USA. mody_reema@lilly.com.
概括
在2型糖尿病 (T2D) 患者的提尔泽帕提德使用显示出有利的坚持和持久性. 大多数患者在随访期间仍然服用较低剂量 (<10毫克),尽管在开始时有常见的并发病和不受控制的糖尿病.
科学领域:
- 药物经济学和健康研究成果研究成果
- 内分泌学和新陈代谢学
- 临床药房实践 临床药房实践
背景情况:
- 蒂尔泽帕提德是一种用于2型糖尿病 (T2D) 的新型降糖剂.
- 了解现实世界的使用模式和患者特征对于优化T2D管理至关重要.
- 之前的研究还没有完全详细介绍美国 Tirzepatide 用户的特征和治疗轨迹.
研究的目的:
- 为了表征T2D患者在美国启动tirezepatide.
- 在6个月的随访期内描述蒂尔泽帕提德的利用模式,包括剂量和治疗修改.
- 为了评估T2D患者治疗蒂尔泽帕提德的坚持和持续性.
主要方法:
- 从2022年5月到2023年1月对医疗保健综合研究数据库 (美国) 的回顾性分析.
- 纳入标准:成年人 (≥18岁) 患有T2D诊断,至少有一次提泽帕提德索赔,并持续招募.
- 用描述性统计数据总结了基线人口统计,临床特征,并发病症和6个月后续剂量,坚持和持续性.
主要成果:
- 15,665名T2D患者开始服用蒂尔泽帕提德;平均年龄为53.2岁,58.5%为女性.
- 常见的并发症包括高血压 (69.2%),脂质失调 (69.2%) 和肥胖 (87.8%与1-3类肥胖).
- 超过一半 (51.2%) 以前使用过GLP-1RA;平均HbA1c为7.6%. 大多数开始于≤5毫克 (84.1%),其中56.5%在6个月后<10毫克. 坚持率为57.5%,持久率为73.3%.
结论:
- 开始服用提尔泽帕提德的患者经常出现多种并发症和不受控制的糖尿病,平均BMI与2类肥胖相一致.
- 蒂尔泽帕提德在这个真实世界T2D人群中表现出有利的坚持和持久率.
- 大多数患者在6个月的随访期间仍然服用低于10毫克的剂量,这表明了常见的定位模式.
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