了解微乳液和纳米乳液在 (透皮) 交付中的理解
Jasmine Musakhanian1, David W Osborne2
1, Gattefossé, Paramus, New Jersey, USA. jasmine.musa@videotron.ca.
AAPS PharmSciTech
|January 10, 2025
概括
微乳液和纳米乳液对于跨膜的安全药物输送至关重要. 本综述澄清了它们的区别和机制,以加强通过皮肤递送药物,重点关注配方成分.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 微乳液和纳米乳液是通过生物膜传递药物的重要药物载体.
- 它们在粘膜和皮肤传递中的有效性得到了充分证实,通常与分散大小和溶解能力有关.
- 现有的文献缺乏微乳液和纳米乳液之间关于定义,行为和特定的透皮输送机制的明确区分.
研究的目的:
- 提供微乳液和纳米乳液之间的概念和实践区别,用于通过皮肤递送药物.
- 探索潜在的作用机制,包括构成和系统组成部分在微观结构中的作用.
- 阐明配方成分对皮肤结构和药物透性的影响.
主要方法:
- 对用于药物输送的微乳液和纳米乳液发表文献的审查.
- 专注于基于三元图的配方系统.
- 分析常用的非离子表面活性剂,共同表面活性剂,共同溶剂和药物应用中的油.
主要成果:
- 确定了了解微乳液与纳米乳液在通过皮肤递送中的具体差异和机制的差距.
- 突出了除了水滴大小之外的因素的重要性,例如半层结构和辅溶剂,油和水比的影响.
- 强调了成分的作用和系统成分的竞争性相互作用,以确定配方行为和皮肤透.
结论:
- 需要对微乳液和纳米乳液系统有更深入的了解,以优化通过皮肤递送药物.
- 构成因素和由此产生的微观结构显著影响药物通过皮肤的透性.
- 对这些不那么明显的机制的进一步研究可以导致更有效的药物配方策略.
相关概念视频
Drug Delivery: Overview
276
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
276
Factors Affecting Dissolution: Particle Size and Effective Surface Area
719
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
719
Non-Oral Extravascular Drug Absorption Routes
194
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
194
Drug Delivery: Enteral Route
375
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
375
Drug Delivery: Miscellaneous Routes
309
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
309
Cellular Membranes and Drug Transport
276
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
276


