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Updated: Jun 3, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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基于生理学的药理动力学/药理动力学建模 (PBPK/PD) 怀孕期间的法莫蒂丁

Xiaomei I Liu1, Dionna J Green2, John van den Anker1

  • 1Division of Clinical Pharmacology, Children's National Hospital, Washington, DC, USA.

Journal of clinical pharmacology
|January 10, 2025
PubMed
概括

这项研究开发了一种基于生理学的药理动力学 (PBPK) 模型,用于怀孕个体的胃灼热药物famotidine. 该模型准确地预测了famotidine水平,显示了妊娠晚期暴露的减少,以及其对胃酸的影响.

关键词:
这种药物是 famotidine.药理动力学是药理动力学的一个方面.基于生理学的药理动力学.怀孕 怀孕 怀孕 怀孕 怀孕

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