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在Murinae亚家族中的Ovgp1基因的分子进化

Miriam Balastegui-Alarcón^1,2, Carla Moros-Nicolás^1,2, José Ballesta^1,2

¹Departamento de Biología Celular e Histología, Facultad de Medicina y de Enfermería, Universidad de Murcia, 30120 Murcia, Spain.

Animals : an open access journal from MDPI

|January 11, 2025

概括

卵巢糖蛋白 (OGP) 基因Ovgp1在小鼠中具有功能,但在老鼠中是一种伪基因. 这项研究将Ovgp1伪基化追溯到1000万年前,并确定GH18家族蛋白质作为潜在的功能替代品.

科学领域:

生殖生物学生殖生物学
基因组学就是基因组学.
哺乳动物进化哺乳动物进化

背景情况:

卵管糖蛋白 (OGP) 是哺乳动物卵管中的主要非血清蛋白,由Ovgp1基因编码.
虽然Ovgp1在小鼠 (Mus musculus) 中具有功能,但它是在老鼠 (Rattus norvegicus) 中是一种伪基.
这两种物种都属于Murinae亚科,这表明Ovgp1损失发生在它们分离后.

研究的目的:

为了确定Ovgp1在动物中伪基化的进化时间.
在Ovgp1非功能性物种中识别可能满足OGP功能的潜在替代蛋白质.

主要方法:

在各种小鼠动物物种中测序特定的Ovgp1基因区域.
分子和蛋白质组分析,以调查GH18家族基因/蛋白质表达在老鼠卵巢.

主要成果:

在Rattini部落的一些物种中证实了Ovgp1的伪原体状态,这表明大多数小鼠物种中的Ovgp1是功能性的.
据估计,Ovgp1的伪基化事件发生在大约1000万年前,即拉蒂尼部落分离后.
在大鼠卵管中检测到几个GH18家族成员 (Chia, Chit1, Chi3l1, Chid1) 的表达.

结论:

大约1000万年前,Ovgp1的伪基化发生在动物的血统中,导致了老鼠.
GH18家族蛋白质在老鼠卵管中表达,并代表OGP的潜在功能同类.
这项研究为探索GH18蛋白质作为假基因载体物种中的OGP功能模仿物提供了基础.

关键词:

这就是为什么Ovgp1 这里是奇特的Chitinases.甘氨基酸酶18家族的甘氨基酸酶 18.卵管是指卵管中的卵管.人类的基因组学.

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