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Updated: Jun 3, 2025

Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate
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Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

Published on: May 19, 2023

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FXR激活通过BMP-2-诱导的小鼠介质干细胞中的COX-2-PGE2-EP4轴加速骨质细胞分化的早期阶段

Ko Fujimori1, Yusuke Iguchi2, Yukiko Yamashita2

  • 1Department of Pathobiochemistry, Faculty of Pharmacy, Osaka Medical and Pharmaceutical University, 4-20-1 Nasahara, Takatsuki 569-1094, Japan.

Molecules (Basel, Switzerland)
|January 11, 2025
PubMed
概括

一个新的Farnesoid X受体 (FXR) 激动剂,FLG390,有效地促进骨质细胞分化. FXR激活通过COX-2-PGE2-EP4通路刺激早期骨形成,为骨代谢控制提供了一个潜在的目标.

关键词:
在COX-2中,COX-2是最常见的.在 FXR 和 FXR 之间.在PGE2的基础上,PGE2介质细胞干细胞介质细胞干细胞骨质母细胞 (osteoblasts) 是一个骨质细胞.

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