计算模拟 基于研究的配方 甲基prednisolone装载纳米颗粒的开发和表征 含有基托和点治疗夜间喘
Vijaya Kumar Voleti1, Ismail Yusuff1, Mohamed Jalaludeen Abdulkadhar2
1Crescent School of Pharmacy, B. S. Abdur Rahman Crescent Institute of Science and Technology, GST Road, Vandalur, Chennai 600048, Tamil Nadu, India.
Polymers
|January 11, 2025
概括
桑糖酸涂层的纳米颗粒有效地为夜间喘提供甲基前列尼索隆. 这种新型药物输送系统在胃肠道中显示持续释放和稳定性,证明安全有效.
科学领域:
- 制药科学 制药科学
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
背景情况:
- 由于其时间和严重程度,夜间喘 (NA) 存在重大挑战.
- 甲基prednisolone (MP) 是一种强大的抗炎性皮质类固醇.
- 有效的药物输送对于管理NA的时代生物学模式至关重要.
研究的目的:
- 开发一种纳米颗粒物药物输送系统,用于甲基前尼索隆 (MP) 治疗夜间喘.
- 为了提高药物释放概况和稳定性,使用奇托 (CH) 和pectin (PEC).
- 创建一个时间调节的输送系统,以改善治疗结果.
主要方法:
- 计算模拟 (基于人工智能的混合分析) 来选择最佳的聚合物.
- 离子凝方法用于制备MP纳米粒子,使用CH和PEC.
- 酸盐酸盐 (CSSC) 涂层用于修改药物释放.
- SEM用于形态学,X射线成像用于稳定性,以及组织病理学用于毒性评估.
主要成果:
- 与CH和PEC配制的MP纳米颗粒显示了球形形态.
- CSSC涂层导致药物持续释放长达24小时.
- X射线成像证实了珠子在酸性pH值中的稳定性;药理动力学研究显示增强了GIT稳定性.
- 组织学评估表明,纳米颗粒在老鼠中无毒.
结论:
- 涂有CSSC的MP纳米颗粒为夜间喘提供了一个有前途的时调制药物输送系统.
- 开发的系统表现出卓越的释放性能和体内稳定性.
- 这种方法增强了甲基prednisolone在NA管理中的治疗潜力.
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